The architecture in Mission is a Spanish blend of materials and labor that is available, the ingenuity of individual monastic, and architectural trends of Spanish America which consists of both Spanish and Italian. Its native techniques and ornamentation was founded in Southern Mexico and in Central and South America. The development of architectural art of buildings has been termed "Ultra Baroque" and has been described as "rhythmically symmetrical," "exuberantly decorated," "pictorially beautiful," possessing "vigorous plastic sentiment coupled with clever and artistic use of polychromic effect."

The church in Mission is known as the Guadalupe church. This historic church dates back to 1899. The original church was partially destroyed by fire in 1925. The statue of the Blessed Virgin that is on the outside front of the church was the only thing rescued from the fire. The church and rectory were built in 1926 and 1927. The church windows are of clerestory design with stained glass. Spiral fluted pillars support the steeple, dome and arched doorways. The priests of the Oblate of Mary Immaculate Order have always manned the church. This church is part of classical moments where it features a model of Greek and roman architecture. Its perpendicular style consists of mullions and transoms, which run vertical and horizontal, and allows huge windows to be filled with stained glass.

The Renaissance style on the steeple places emphasis on symmetry, proportion, geometry and the regularity of parts as they are demonstrated in the architecture of classical antiquity and in particular ancient Roman architecture. It has orderly arrangements of columns and the pilasters have a semicircular arch. This church is very different from several others in the Rio Grande valley because the style of this particular architecture is still based in Renaissance time; therefore, others like St. Mary’s have become more modern and less traditional.